Tezepelumab is a new drug being developed by Astra Zeneca and Amgen for severe asthma. Tezepelumab is an injectable medication, recent mid stage clinical trials showed that it reduced asthma exacerbations between 61-71% depending on the dose for severe asthmatics.
Currently there are three asthma injectable medications on the market. The most recent two that were approved are Nucala and Cinqair, these medications target IL-5 which is a major producer of eosinophils in the blood and tissues (eosinophils are responsible for airway inflammation and asthma). Tezepelumab works differently than Nucala and Cinaqair as it targets TSLP (Thymic stromal lymphopoietin). TSLP is a key regulator in asthma pathogenesis.
Tezepelumab is different because it acts further upstream in the inflammatory cascade responsible for asthma by blocking the action of a cell-signalling protein called thymic stromal lymphopoietin (TSLP).
TSLP is an epithelial cytokine produced in response to pro-inflammatory stimuli such as allergens, viruses and other pathogens in the lung. It drives the release of downstream T2 cytokines including IL-4, IL-5 and IL-13, leading to inflammation and asthma symptoms. TSLP also activates many types of cells involved in non T2 driven inflammation. Therefore, the early, upstream activity of TSLP in the inflammation cascade has been identified as a potential target across a broad asthma population.
Tezepelumab may be able to treat a wider of range of asthma patients according to Astra Zeneca’s head of respiratory. Tezelpelumab is also being developed for atopic dermatitis.
Dupilumab which is currently approved for atopic dermatitis and is currently being developed for asthma, had recent disappointing new for its asthma studies. In its late stage trials, it only reduced severe asthma attacks by 46%, compared with 71% in its mid stage data. It remains to be seen how Tezepelumab will do in its late stage data in the future.
There is no current brand name yet for Tezepelumab and there is no current information on pricing of Tezepelumab either. Nucala and Cinqair are both currently priced at several thousand dollars a month, so expect Tezepelumab to fall within the same price range.
If you currently suffer from severe asthma, speak to your allergy and asthma doctor to see what treatment is right for you. Nucala and Cinqair both target eosinophils, if you don’t fit that criteria speak to your doctor about what treatment options are best available. Xolair is another biological medication for severe asthma that targets IgE. This medication has been out for over 10 years and it is also used for chronic idiopathic urticaria. It remains to be seen what criteria would be needed for Tezepelumab and TSLP and if it gets FDA approval in the future.