Xhance is a new nasal spray to be available April 2018. Xhance is indicated for the the treatment of nasal polyps in patients 18 years or older. The active ingredient in Xhance is fluticasone propionate 93 mcg. If that sounds familiar, fluticasone propionate is the active ingredient in Flonase. What is different from Xhance from other nasal sprays is the delivery system of the medication.
The nasal spray delivers the medication “high and deep in the nasal passages, where nasal polyps originate and most sinuses drain and ventilate”, according to the company Optinose. The delivery of the medication is done by the person exhaling into the devices mouthpiece and the medicine comes out through another area into the patients nose. The device seals the nostril and allows for the transfer of pressure from the mouth into the nose. Further from the company “air then enters one nostril through the sealing nosepiece, helping expand narrow nasal passages with naturally warm, humid air.” They continue, “medication is delivered around obstructions, filling the nasal passages and depositing drug high and deep (including the ostiomeatal complex, where most polyps originate and where most sinuses drain and ventilate.”
If you have been reading our blogs, nasal polyps is a serious and chronic problem for allergy sufferers. Many patients with nasal polyps have diminished quality of life. Even when a patient does get surgery for nasal polyps, most of them seem to grow back and patients need multiple surgeries.
Of all the nasal sprays currently on the market, Nasonex is indicated for nasal polyps only. Even then though, patients taking Nasonex seem to have recurrences of their nasal polyps. According to the company “with XHANCE treatment, patients experienced statistically significant reductions of both nasal congestion/obstruction at week 4 and total polyp grade at week 16, which were the co-primary endpoints.” Other steroidal nasal sprays that are available over the counter (OTC), Nasocort, Rhinocort, Flonase Sensimist, are indicated for allergic rhinitis only
The dosing of Xhance will be 1-2 sprays per nostril twice a day. Pricing is not currently available, but it will most likely be equivalent to Nasonex. The most common side effects seen were, bleeding from the nose, nasal septum ulcers, nasopharyngitis, nasal erythema, congestion, sinusitis and headaches.
Xhance will be a prescription medication only and it will only be for nasal polyps. If you have nasal polyps and are looking for treatment options see your ENT or allergy doctor.