JAK inhibitors for asthma are currently being studied. Asthma is an inflammatory disease of the airways characterized by intermittent episodes of wheezing, chest tightness and cough. Many of the inflammatory pathways implicated in asthma involve factors that activate the Janus Kinase (JAK). The discovery of the Janus kinases activator of transcription (STAT) signaling pathway was […]
PEG Allergy and Vaccine Allergy
PEG allergy has become an important topic since the COVID-19 vaccine rollout. There are 2 messenger RNA vaccines that have been approved in multiple countries around the world. Pfizer Covid Vaccine and Allergy Moderna Covid Vaccine and Allergy There are 3 adenovirus vector vaccines as well. Johnson and Johnson Covid Vaccine and Allergy Since the vaccine […]
Should you taken an antihistamine before allergy shots?
An antihistamine before allergy shots may help prevent adverse reactions. Allergy shots is the only potential disease modifying treatment for allergic diseases (oral immunotherapy is also as well). The typical process of allergy immunotherapy involves regular administration of increasing doses of sensitizing allergy to a targeted maintenance dose. Allergy immunotherapy can come in different routes, […]
Opzelura (ruxolitinib) for Eczema
Opzelura (ruxolitinib) has been FDA approved for eczema. Opzelura is a topical JAK inhibitor, and its indicated for short term use in patients 12 and up who have mild to moderate atopic dermatitis. It is the first topical janus kinase inhibitor approved in the United States. Currently for atopic dermatitis topical treatment, the mainstay of […]
Allergy and Eustachian Tube Dysfunction
Is there a link between allergy and eustachian tube dysfunction? Symptoms of eustachian tube dysfunction are: fullness in the ears feeling like your ears are “plugged” changes to your hearing ringing in the ear clicking or popping sounds ticklish feelings in the ears pain The Eustachian tube is a small passageway that connects your throat […]
Upadacitinib for Atopic Dermatitis (Eczema)
Upadacitinib is an oral JAK1 inhibitor being developed for patients with severe atopic dermatitis. Multiple phase 2 randomized placebo controlled studies have examined the efficacy of upadacitinib in adults and adolescent patients with moderate to severe atopic dermatitis. Published in The Lancet, 2 replicate 16-week trials showed that monotherapy with upadacitinib improved symptom and disease severity compared […]
Tomato Allergy can come in many flavors
Tomato allergy is not commonly reported, but it can cause adverse reactions. Hypersensitivity reactions to other fruits are commonly reported, particularly apples, stone fruits and bananas. Tomato (Solanum lycopersicum) is derived from two wild ancestor species, Solanum pimpinellifolium and Solanum cerasiforme. Tomato flavor is a balance of acid and sugar recognized by the tongue and […]
Can you outgrow fish allergy?
The data of whether someone can outgrow fish allergy is scarce. Fish allergy is one of the most common causes of food allergy, especially in children and young adults, with rates from 0.1 to 0.5%. The major fish allergen identified is beta-parvalbumin, it is resistant to heat and digestion. Many patients with an allergic reaction […]
Eczema and Dementia Risk
Past studies have suggested that there is a link between eczema and dementia. Patients with dementia have a higher prevalence of eczema than those without. According the the World Health Organization, eczema (atopic dermatitis) is 15th among all nonfatal diseases and is the largest disease burden among all skin diseases. Eczema peaks in early childhood, […]
When can you stop inhaled steroids for asthma?
Inhaled steroids for asthma is the recommended first-line treatment for patients who are uncontrolled. Inhaled steroids have led to fewer hospitalizations and deaths over the past 10-15 years. Recent Global Initiative for Asthma guidelines, recommend in mild asthma, intermittent use of an inhaled steroid and long acting beta-2 agonist (LABA) on an as needed basis […]