Lirentelimab is an anti-sialic acid-binding immunoglobulin-like lectin 8 mAb that selectively inhibits mast cells and depletes eosinophils. It is being studied for chronic urticaria that is often refractory to standard therapy. Stepwise approach to Chronic Urticaria (Chronic Hives) Chronic urticaria is a mast cell disease that causes recurrent itching, hives and angioedema for more than […]
Dupixent for EoE (Eosinophilic Esophagitis); FDA approved and New Dosing
Dupixent for EoE (eosinophilic esophagitis) was recently approved by the FDA. This will be the first drug officially approved for EoE. Eosinophilic Esophagitis is a chronic inflammatory immune disorder of the esophagus where eosinophils (a type of white blood cell) builds up in the esophagus. This can cause symptoms of difficulty swallowing, eating or food […]
What are the best foods for Asthma?
As an asthma doctor, I am often asked what are the best foods for asthma? Before we begin, it should be noted that no foods will help relieve an asthma attack. But your daily diet plays a role in your overall health to keep you healthy and reduce symptoms of asthma. Asthma is a chronic […]
Best Nasal Polyps Treatment
With so many options available, the best nasal polyps treatment can be hard to pick. Chronic rhinosinusitis with nasal polyps is an inflammatory disease of the upper airways characterized by polyp growth in the nasal passages. It causes severe congestion, discharge and difficulty with smell. The best treatment option is unclear. A study published in […]
Fasenra for Nasal Polyps, a new treatment option
Fasenra for nasal polyps is currently being studied as a future therapeutic option. Chronic sinusitis with nasal polyps is an inflammatory condition associated with symptoms that may be severe, including rhinorrhea, nasal blockage and congestion, loss of smell, facial pressure/pain. Nasal sprays have shown limited help and surgery only helps temporarily as many of them […]
Asivatrep a new topical treatment for Eczema
Asivatrep is a new potential treatment for eczema (atopic dermatitis). Atopic dermatitis is a chronic inflammatory itchy skin disease that affects up to 25% of children and 10% of adults. The cause is complex and multifactorial. Currently there are few classes of topical medications to treat it. Steroids Calcineurin inhibitors (Elidel, Protopic) Phosphodiesterase 4 inhibitors Eucrisa […]
Kiwi Allergy can come in many flavors
Kiwi allergy is not commonly reported, but it can cause adverse reactions. Hypersensitivity reactions to other fruits are commonly reported, particularly fruits in the birch tree family: apple, hazelnut, carrot and potato, these may be symptoms of oral allergy syndrome. Kiwi is also known as a Chinese gooseberry. Kiwi has a slightly acidic flavor that […]
Ana o 3 IgE in diagnosing Cashew Nut Allergy
Cashew nut allergy is on the rise, Ana o 3 IgE seems to be the best single test to diagnose cashew allergy. Cashew nut belongs to the Anacardiaceae family, along with pistachio nut and mango. Cashew and pistachio nut cross-react both in IgE testing and clinically. Cashew nut is typically consumed as a snack and […]
Does Expired Albuterol work?
Does expired albuterol work? Expiration dates of pharmaceutical products are important to know. They are based on stability studies conducted by manufacturers. Expiration dates imply that the medications no longer retain their potency and should be discarded once its reached, but in facts, the post expiration residual drug strength is usually undetermined. In fact in […]
Itepekimab in Asthma and COPD
Itepekimab is an anti-Il-33 monoclonal. Il-33 is an epithelium-derived cytokine that promotes Th2 immune responses in response to cellular damage with roles in asthma and COPD (Chronic Obstructive Pulmonary Disease). Two randomized controlled clinical trials were performed assessing the efficacy of Itepekimab in asthma and COPD. After identifying the asthma associated variants in the genes […]