Los Angeles Allergist

Los Angeles Allergist

Alan Khadavi, MD, APC
  • Home
  • Meet Dr. Khadavi
  • Conditions We Treat
  • Your First Visit
  • Insurance Accepted
  • Allergy and Asthma Info
    • Asthma Info
    • Allergic Rhinitis
    • Allergic Triggers
  • Blog
  • Media
  • Contact Us

9001 Wilshire Blvd. Suite 204
Beverly Hills, CA 90211
Phone: 310-282-8822

16260 Ventura Blvd., Suite 140
Encino, CA 91436
Phone: 818-528-7776

December 1, 2016 by Alan Khadavi

Omalizumab (Xolair) for treating Angioedema and Chronic Hives

Omalizumab (Xolair) is being used to treat chronic hives (urticaria).  Chronic idiopathic/spontaneous urticaria (CIU/CSU) is characterized by the spontaneous appearance of hives, angioedema or both that recur without specific external stimuli for at least 6 weeks.  Angioedema, which is the acute deeper swelling of the lower skin or subcutaneous tissue has been reported to occur in approximately 40% of patients with CIU/CSU.

Antithistamines have been available to treat hives.  Nonsedating antihistamines are used more now to threat hives.  Although being used up to 4 times a day of antihistamines, many patients still remain symptomatic with hives and urticaria.

Stepwise approach to Chronic Urticaria (Chronic Hives)

Omalizumab is a humanized anti-IgE monoclonal antibody that is used as add-on therapy for the treatment of chronic hives in adults and adolescents at least 12 years of age with inadequate response to H1 antihistamines.

A recent study published in the Annals of Allergy Asthma and Immunology showed the results of patients with chronic hives and angioedema treated with Omalizumab.  These patients have failed H1-antihistamines up to 4 times a day plus Singulair.

Conclusion:  Treatment with 300mg of omalizumab was efficacious in reducing patient-reported angioedema for patients with chronic idiopathic urticaria/chronic spontaneous urticaria, who were symptomatic despite a variety of treatments.  Most patients reported that they did nothing or took H1-antihistamines to mange their angioedema if they got them.  There were a few reports of high intensity interventions for angioedema management.

In summary, treatment with 300 mg of omalizumab can help patients with chronic hives and angioedema in whom antihistamine treatment is failing by reducing the number of days with angioedema they experience.  If you are experiencing hives, contact your local allergist or allergy doctor to explore what treatment options are best for you.  In this article we have discussed chronic hives, which is different from acute hives (urticaria).  Acute hives is defined as hives for less than 6 weeks duration.  The work up, management and treatment of acute hives differs from chronic urticaria.  Xolair (omalizumab) is not indicated for acute hives.

Response of hives after treatment with Xolair

 

 

Filed Under: Allergy Medicine, angioedema, Blog, Urticaria

alan-khadavi
Dr. Alan Khadavi
Allergy & Asthma Specialist

Latest Posts

January 22, 2023

Is Benadryl Safe to use, or is it Time to Move on?

is benadryl safe

January 12, 2023

Airsupra for Asthma, a new rescue medication

airsupra

December 26, 2022

Cantaloupe Allergy comes in many flavors

cantaloupe allergy

December 23, 2022

Remibrutinib, a BTK inhibitor for Chronic Hives

remibrutininb

November 21, 2022

Eczema and Hard Water, is there a link?

eczema and hard water

November 19, 2022

Nucala, Fasenra or Dupixent for Severe Eosinophilic Asthma?

nucala fasenra dupixent

November 18, 2022

Xolair for idiopathic angioedema

xolair for idiopathic angioedema

September 29, 2022

When will my child outgrow egg allergy?

outgrow egg allergy

September 13, 2022

Can you be allergic to water? (Aquagenic Urticaria)

allergic to water

September 8, 2022

Oclacitinib for Atopic Dermatitis (Eczema) in Dogs

oclacitinib

Read More Posts...

Follow Us…

© 2023 Allergy Los Angeles. All Rights Reserved · Log in · Return to top of page