Cold hives (or urticaria), is a subtype of physical hives that is characterized by the development of hives and swelling in response to cold exposure and rewarming of the skin. It is related to the histamine release of mast cells. Several studies have shown that it is related to IgE and an unknown skin autoallergen […]
Can Asthma cause Postpartum Depression?
Can asthma cause postpartum depression? Asthma is one of the most common chronic diseases that can complicate pregnancy. It can put women at increased risk of pregnancy outcomes. Postpartum depression is a nonpsychotic depressive episode that begins after delivery, most occur 1 to 3 months after delivery, but its onset may occur as late as […]
Gut microbiome in food allergy
The gut microbiome (bacteria) can play a strong role in food allergies. Food allergy is a clinical and public health problem that affects up to 10% of the US population. It is defined as an adverse health effect arising from a specific immune response that occurs on exposure to a food. IgE food mediated allergy […]
New Sublingual Tree Tablet
A new sublingual tree tablet is currently being developed for the treatment of tree pollen induced allergic rhinoconjunctivitis. Allergic rhinitis is estimated to affect 500 million individuals worldwide and is considered a global health problem. It leads to lower school and work performance. Allergic rhinitis is also a risk factor for asthma development. Currently allergy […]
Can you outgrow seafood allergy?
There have not been many studies to see whether someone can outgrow seafood allergy unlike peanut allergy where 20% is considered the norm. Can you outgrow peanut allergy? Seafood allergy includes allergy to either fish or shellfish although the main allergenic proteins differ between these groups. Worldwide prevalence of allergy to fish is reported to […]
Ryaltris Nasal Spray for Allergic Rhinitis
Ryaltris is a new nasal spray (formerly GSP301) that is being investigated by Glenmark Pharmaceuticals for the treatment of seasonal allergic rhinitis in patients 12 years and older. Ryaltris consists of 2 drugs, the first one is olopatadine hydrochloride, a nasal antihistamine, which is the medication used in Patanase nasal spray. The second medication […]
Tree Nut Allergy: Is it the new Peanut Allergy?
Tree nut allergy is usually lifelong and together with peanut allergy are the most common cause of food induced anaphylaxis. There is not as much data compared to peanut allergy. Children with peanut allergy are thought to be at increased risk of tree nut allergies, with around 30% of pediatric patients presenting with peanut allergy […]
Adult Eczema: A Clinical Review
Approximately 1 in 4 adults report the onset of adult eczema and the rest its onset is from childhood. Eczema is an ill-defined skin lesions and it includes patches, papules, and plaques with different degrees of redness and swelling. It can affect any skin site but they most classically affect the creases of the elbows […]
Fezakinumab an IL-22 antagonist for Eczema
IL-22 upregulation characterizes atopic dermatitis lesions. However, blocking IL-22 has not been defined in human subjects. A recent study sought to evaluate the cellular and molecular effects of fezakinumab (anti-IL-22) versus placebo taken from biopsy specimens. Atopic dermatitis is the most common chronic inflammatory skin disease with increasing prevalence. IL-4 and IL-13 are the 2 […]
Tralokinumab for Atopic Dermatitis
Tralokinumab is a fully human monclonal antibody that potently and specifically neutralizes IL-13. IL-13 has an important role in atopic dermatitis pathogenesis. Atopic dermatitis (eczema) is a chronic inflammatory skin disease. It can affect sleep, psychosocial activities and health related quality of life. The symptoms of many patients are not controlled with current treatment regimens. […]