Mast Cell Activation Syndrome (MCAS) is a condition in which mast cells release chemical mediators, such as histamine, leukotrienes, and prostaglandins, inappropriately or excessively. These chemicals can cause symptoms involving several parts of the body, including the skin, gastrointestinal tract, lungs, and cardiovascular system. Possible symptoms include: Flushing, itching, or hives Swelling Abdominal cramping, nausea, […]
Nucala vs. Fasenra for Severe Asthma: Which Biologic Is Better?
Nucala vs. Fasenra for Severe Asthma: Which Biologic Is Better? For patients with severe eosinophilic asthma, biologic medications can dramatically reduce asthma attacks and the need for oral steroids. Two commonly used options are Nucala (mepolizumab) and Fasenra (benralizumab). Both target eosinophilic inflammation, but they work in slightly different ways. What Is Eosinophilic Asthma? Eosinophils […]
Psyllium Allergy: Symptoms, Anaphylaxis, and Hidden Sources
Psyllium has become a popular ingredient in fiber supplements, digestive-health products, and gluten-free foods. Most people tolerate it well, but in rare cases, psyllium can trigger a true allergic reaction. Because psyllium may appear in products people do not think of as “allergenic,” reactions can be difficult to recognize. What Is Psyllium? Psyllium comes from […]
Are Allergies More Common After COVID-19? What We’re Learning About the Post-COVID Immune System
Since the COVID-19 pandemic, many allergists have heard a similar question from patients: “I never had allergies before COVID. Why am I suddenly reacting to everything?” Patients may describe new nasal congestion, sneezing, itchy or watery eyes, wheezing, hives, skin irritation, or sensitivity to environmental triggers after recovering from COVID-19. While researchers are still determining […]
Why Am I Suddenly Allergic to Everything? Understanding Adult-Onset Allergies
You made it through childhood without allergies. You could eat almost anything, spend time around pets, and enjoy spring without constantly sneezing. Then suddenly, as an adult, things seem different. Maybe certain foods make your mouth itch. You develop hives for no apparent reason. Your nose is constantly congested. A friend’s cat suddenly makes your […]
EpiPen vs. neffy: Which Epinephrine Option Is Right for Anaphylaxis?
For decades, people at risk for anaphylaxis have relied on epinephrine auto-injectors such as EpiPen. A newer option, neffy, delivers epinephrine as a needle-free nasal spray. Both products contain the same active medication—epinephrine—and are intended for the emergency treatment of serious allergic reactions, including anaphylaxis. However, they deliver the medication differently and have distinct practical […]
OX40/OX40L Inhibitors: Are Amlitelimab and Rocatinlimab the Next Generation of Atopic Dermatitis Treatment?
Atopic dermatitis (eczema) treatment has advanced dramatically over the past decade. The introduction of biologic therapies such as dupilumab and tralokinumab, along with oral JAK inhibitors, has transformed care for many patients with moderate-to-severe disease. Yet many patients continue to experience incomplete responses, loss of efficacy over time, or frequent flares. One of the most […]
Can You Be Allergic to Collagen? What You Need to Know About Collagen Supplements and Allergic Reactions
Collagen supplements have become one of the most popular health products in recent years. They’re marketed to improve skin, hair, nails, joints, and overall wellness. But if you’ve developed hives, itching, swelling, or another reaction after taking collagen, you may wonder whether you’re allergic to collagen itself. The answer is more nuanced than most people […]
Opzelura vs. Zoryve: Which New Non-Steroid Cream Is Right for Eczema?
Opzelura vs. Zoryve: Which New Non-Steroid Cream Is Right for Eczema? Atopic dermatitis (eczema) affects millions of children and adults, causing itching, inflammation, sleep disruption, and a significant impact on quality of life. While topical corticosteroids remain a cornerstone of treatment, many patients are looking for effective steroid-free options that can be used long term. […]
Low-Dose GLP-1 Inhibitors for Mast Cell Activation Syndrome (MCAS): Could They Help?
Over the last year, a growing number of physicians and patients in the mast cell activation syndrome (MCAS) community have begun discussing an unexpected treatment approach: very low-dose GLP-1 receptor agonists such as semaglutide or tirzepatide. While these medications were originally developed for diabetes and obesity, some clinicians are now reporting improvement in inflammation, histamine-related […]