Abrocitinib is currently being developed by Pfizer for the treatment of atopic dermatitis (eczema). It is an investigational oral once-daily Janus kinase 1 (JAK1) inhibitor. The JAK/STAT pathway is an important factor in inflammation and itch in atopic dermatitis. There are multiple receptors and signaling cascades involved in eczema related inflammation and itch, one of these […]
Is Clarinex safe during Pregnancy?
Is Clarinex safe during pregnancy? Clarinex, generic name is desloratadine does not have safety data to use during pregnancy. Loratadine (Claritin) has been previously studied and found no risk of adverse fetal outcomes during pregnancy and is considered safe. Desloratadine is the main active metabolite of Loratadine. In a previous post we described the difference […]
Breztri new inhaler for COPD by AstraZeneca
Breztri is a new inhaler that will be approved for COPD. Breztri is a combination of 3 medications, budesonide/glycopyrronium/formoterol fumarate. Each of these medications have been used to treat COPD (chronic obstructive pulmonary disease), and used in combination, it has been shown to decrease the rate of moderate or severe exacerbations. We have spoken about […]
Can you outgrow tree nut allergies?
A question asked by many patients is, can you outgrow tree nut allergies? Tree nuts are common causes of food related allergic reactions and anaphylaxis. Resolution of tree nut allergy is thought to be now, yet studies are limited. In a previous blog post, we explored the rates of outgrowing peanut allergy. Can you outgrow […]
Your Gut and Asthma, what role do they play?
Recent evidence has shown the importance of the gut and asthma. The gut biome is linked to airway disease through modification of the the immune response, which is called the gut-lung axis. In allergic asthma, altered gut microbiome has been reported to augment allergic sensitization. Studies have shown that the use of antibiotics and a […]
High dose Xolair for chronic hives
High dose Xolair may be a treatment option for patients with chronic hives who fail the standard treatment dose of 300mg monthly. Xolair (omalizumab) is a monoclonal anti-IgE antibody for patients who have chronic spontaneous urticaria who fail the 4 fold standard dosing of antihistamines. Stepwise approach to Chronic Urticaria (Chronic Hives) A recent study […]
How does Dupixent work?
How does Dupixent work? Dupixent is currently indicated for patients who have atopic dermatitis, asthma and nasal polyps. Dupixent works by inhibiting IL4 and IL13 and it has improved outcomes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). A recent study published in Allergy studied Dupixent’s local effects on type 2 inflammatory biomarkers. The study […]
Omalizumab for Atopic Dermatitis
Omalizumab for atopic dermatitis has shown promising results. In JAMA Pediatrics, the researchers have demonstrated for the first time that omalizumab, which neutralizes IgE, reduced disease severity and improved quality of life in pediatric patients with severe atopic dermatitis. This was the case even in subjects with very high baseline total plasma IgE levels. Omaizumab […]
Generic Dymista Now Available
Generic Dymista is now available. Dymista consists of 2 ingredients that treat allergic rhinitis, fluticasone and azelastine. Apotex is a Canadian pharmacy who will be manufacturing this product. Dymista is approved for the relief of symptoms of seasonal allergic rhinitis in patients 6 years of age and older who require treatment with both azelastine hydrochloride and […]
Joe Biden’s Allergies and Asthma (A summary)
Joe Biden’s allergies are a significant part of his medical history. Vice President Joe Biden has released his medical summary history and in it there are notable findings pertaining to allergies and asthma. Joe Biden Medical History He has a history of atrial fibrillation, hyperlipidemia, acid reflux and seasonal allergies. Under the seasonal allergies category […]