Three anti-IL-5 pathway directed therapies are approved for use in patients with severe eosinophilic asthma, however no head to head comparison data are available. Nucala (mepolizumab) and Cinqair (reslizumab) target IL-5 and Fasenra (benralizumab) binds to the IL-5 receptor. All 3 therapies have demonstrated statistically significant reductions in exacerbation rates. Additionally, Nucala and Fasenra reduced […]
Other Conditions in Eosinophilic Esophagitis
Eosinophilic esophagitis is a chronic immune-mediated inflammatory condition characterized by eosinophils infiltrating the esophagus occurring in 1 in 2,000 individuals. Since the 1990’s its incidence has been increasing and it is the most common cause of chronic swallowing problems in the developed world. It is characterized by a food allergy-driven process, with a high rate […]
New Eczema Medications in the Pipeline
In the past year or so, new eczema medications have been released that have been highly beneficial for patients. We have seen Eucrisa (crisaborole) New Eczema Medication gets FDA Approval, this is a topical medication which is an inhibitor of phosphodiesterase 4-depndent cyclic adenosine monophosphate degradation. It was approved in 2016 for mild to moderate atopic […]
Bethenny Frankel Suffers Allergic Reaction
Bethenny Frankel from the hit reality show, Real Housewives of New York, suffered what was reported an anaphylactic episode. In a previous season of her show, she had a reaction after eating fish, she has stated that she has a rare fish allergy. This most recent episode occurred after eating soup which contained fish in […]
AR201 a treatment for Egg Allergy by Aimmune
AR201 is currently being developed by Aimmune Therapeutics for the treatment of egg allergy. If Aimmune sounds familiar to you, it is because they will be releasing the first treatment of peanut allergy by the end of 2019, AR101. AR101 a Potential Peanut Allergy Cure Aimmune expects to initiate a Phase 2 clinical trial of […]
Am I Allergic to Penicillin?
Recent studies have shown that more than 90% of patients labeled as allergic to penicillin were found to be tolerant of penicillin. Current guidelines encourage routine penicillin allergy verification because of substantial clinical and economic consequences of a penicillin allergy label.However, penicillin testing can be prohibited by time, personnel and resource constraints. A recent study […]
Food Allergy and C-sections, what is the influence?
A recent study looked at the correlation of food allergy and birth conditions. Namely the association between C-sections, preterm birth, low birth weight, small for gestational age, large for gestational age and low Apgar scores and future food allergy. The prevalence of food allergy is increasing and there is an interest in environmental components, very […]
When multiple epinephrine doses are needed for food anaphylaxis
Multiple epinephrine dosages are sometimes need for anaphylaxis. Anaphylaxis is a severe, potentially fatal allergic reaction. Intramuscular epinephrine is the recommended treatment in the the setting of anaphylaxis and the current recommendation is for patients to carry 2 doses of self-injectable epinephrine. Previous studies have evaluated food-induced allergic reactions that require multiple epinephrine injections in […]
NBA Rookie Zhaire Smith’s Allergic Reaction
In reported news today, Zhaire Smith of the Philadelphia 76’ers will be out possibly the whole NBA 2018-2019 season due to complications from an allergic reaction. It was known that the rookie had a peanut allergy and food was individually prepared for him at the teams facility so he was not exposed to peanut. Apparently […]
Primatene Mist OTC gets FDA Approval
Primatene Mist OTC is making a comeback as it was recently FDA approved. Primatene Mist was taken off the market in the past because it contained CFC propellants that destroyed the ozone layer, we discussed this several years ago. Primatene Mist not likely to get FDA approval But the new version of Primatene Mist OTC […]