Since the release of dupilumab for atopic dermatitis, studies are currently underway to investigate dupilumab for nasal polyps, asthma and a host of other conditions. Dupilumab is a human monoclonal antibody against interleukin 4 and 13. A study published in JAMA titled “Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis […]
Pet Allergies and Asthma
Pet allergies and asthma are big problems in this country. Pet allergy in the home, notably sensitization to cats and dogs, is a strong predictor of the development of childhood asthma. More cases of asthma could be attributed to cat allergen than any other sensitization. Other investigations have shown that there is a protective effect […]
Risk Factors for Eosinophilic Esophagitis
With the rise of eosinophilic esophagitis being diagnosed in the United States, there likely is a contributing factor. This is evidenced from twin studies that show stronger disease concordance in twins compared with non twin siblings, suggesting that early-life factors contribute. Studies have shown that environmental factors account for nearly 85% of the disease cause. […]
Nucala (mepolizumab) vs. Cinqair (reslizumab)
In a study published in The American Journal of Respiratory Critical Care Medicine, investigators compared intravenous reslizumab (Cinqair) and mepolizumab (Nucala). Both of them are used for moderate to severe persistent asthma and they both neutralize IL-5, which produces blood eosinophilia and leads to severe eosinophilic asthma. A randomized, placebo controlled trial was used to […]
AR101 a Potential Peanut Allergy Cure
AR101 is currently being studied by Aimmune Therapeutics to induce desensitization in peanut allergic subjects. The peanut treatment, AR101, passed through phase 2 trials in 2016, protecting 100% of patients who ate 443 mg of peanuts (1.5 peanuts), 90% of those who ate 1,043 mg (3 peanuts) and 60% who ate 2,043 mg (7 peanuts). A single […]
Food Diversity and Allergic Disease
Food diversity has been a hot topic in allergy since several clinical trials in high-risk children reported that early introduction of highly allergenic foods, especially peanut and egg, prevents food allergy later in life. This opened up the debate about changing recommendations about the timing of solid food introduction and the length of breast feeding […]
Allergy to Marijuana
Allergy to marijuana has been on the rise with the legalization of medical marijuana and recreational marijuana in certain states. Here in California, recreational marijuana has become legalized on January 1st, 2018. Medical marijuana has been legal for more than 20 years but now with the full legalization in California, there will be more reactions […]
Do Asthma Spacers Help?
The use of asthma spacers for asthma management has been widely accepted for years. However, a remaining concern is that incorrect use of a spacer is common and may lead to poor asthma control. Asthma spacers can be used in conjunction with short acting beta agonists and inhaled corticosteroids. Coordinating device sprays while inhaling an […]
Severe Hives Treatment (Xolair and Cyclosporine)
Severe hives or chronic spontaneous urticaria is classified as hives with or without swelling that occurs for 6 weeks or more with an unknown cause. The prevalence of chronic hives (also known as chronic idiopathic urticaria) is approximately 0.5% to 5% of the population. Chronic hives may be active for 1-5 years at a time, […]
Do Bleach Baths Improve Eczema?
Eczema or atopic dermatitis is a chronic, relapsing inflammatory skin disorder affecting 15%-20% of children and 1%-10% of adults in the U.S. and worldwide. Deficiencies in the skin barrier and immune system dysfunction contribute to eczema, resulting in dryness and itching. Eczema patients are predisposed to to skin infections and patients have a high concentration […]
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