Los Angeles Allergist

Los Angeles Allergist

Alan Khadavi, MD, APC
  • Home
  • Meet Dr. Khadavi
  • Conditions We Treat
  • Your First Visit
  • Insurance Accepted
  • Allergy and Asthma Info
    • Asthma Info
    • Allergic Rhinitis
    • Allergic Triggers
  • Blog
  • Media
  • Contact Us

9001 Wilshire Blvd. Suite 204
Beverly Hills, CA 90211
Phone: 310-282-8822

16260 Ventura Blvd., Suite 140
Encino, CA 91436
Phone: 818-528-7776

January 29, 2018 by Alan Khadavi

Risk Factors for Eosinophilic Esophagitis

With the rise of eosinophilic esophagitis being diagnosed in the United States, there likely is a contributing factor.  This is evidenced from twin studies that show stronger disease concordance in twins compared with non twin siblings, suggesting that early-life factors contribute.  Studies have shown that environmental factors account for nearly 85% of the disease cause.  A recent study published in The Journal of Allergy and Clinical Immunology, looked at the risk factors for eosinophilic esophagitis.  Investigators sought to determine the association between prenatal, intrapartum and postnatal factors in the development of eosinophilic esophagitis.

The following was observed:

  • Prenatal (maternal fever, preterm labor) was associated with increased risk.
  • C-section delivery was associated with a 77% increased risk for Eosinophilic Esophagitis.
  • Antibiotic use in infancy was associated with a 130% increased risk.
  • Use of acid suppressors in infancy was strongly associated with risk of Eosinophilic Esophagitis
  • Presence of furred pets in infancy was protective for Eosinophilic Esophagitis.

It is apparently not associated with breast-feeding, maternal multivitamin or folic acid supplement use.

Patients with eosinophilic esophagitis often have other atopic comorbidities (asthma, allergic rhinitis), respond to elimination diets, relapse on food re-exposure and have an allergic TH2 response in the esophagus.  All of this suggests that the disease is allergen related.

This study shows that many of the factors identified are potentially modifiable and are areas for prevention.

It is important that if you are diagnosed with eosinophilic esophagitis that your gastroenterologist and allergist work together to tailor the best treatment approach.  There are multiple diagnostic tests and treatment options that are available for patients with this disease.

To read more about factors for eosinophilic esophagitis and treatment options, please click on the links below.

Eosinophilic Esophagitis (EoE)

Eosinophilic Esophagitis Treatment Options

Eosinophilic Esophagitis in Southern California

There are several current studies underway for medications that target the production of eosinophils.  IL-5 is a major target of these drugs, there are currently 3 on the market.

New Asthma Drug Nucala (Mepolizumab) for Severe Eosinophilic Asthma

Cinqair (Reslizumab) for Eosinophil Disorders (formerly Cinquil)

Fasenra (Benralizumab) for Severe Asthma

 

Filed Under: Blog, Food allergy, Pediatric

alan-khadavi
Dr. Alan Khadavi
Allergy & Asthma Specialist

Latest Posts

January 22, 2023

Is Benadryl Safe to use, or is it Time to Move on?

is benadryl safe

January 12, 2023

Airsupra for Asthma, a new rescue medication

airsupra

December 26, 2022

Cantaloupe Allergy comes in many flavors

cantaloupe allergy

December 23, 2022

Remibrutinib, a BTK inhibitor for Chronic Hives

remibrutininb

November 21, 2022

Eczema and Hard Water, is there a link?

eczema and hard water

November 19, 2022

Nucala, Fasenra or Dupixent for Severe Eosinophilic Asthma?

nucala fasenra dupixent

November 18, 2022

Xolair for idiopathic angioedema

xolair for idiopathic angioedema

September 29, 2022

When will my child outgrow egg allergy?

outgrow egg allergy

September 13, 2022

Can you be allergic to water? (Aquagenic Urticaria)

allergic to water

September 8, 2022

Oclacitinib for Atopic Dermatitis (Eczema) in Dogs

oclacitinib

Read More Posts...

Follow Us…

© 2023 Allergy Los Angeles. All Rights Reserved · Log in · Return to top of page