In the July 2014 edition of The Journal of Allergy and Clinical Immunology, CVID was examined.
It was a retrospective study that examined 2212 patients with the disease. They found more than 1/3 of patients presented at an early age, less than 10 years old, which is much more frequent than earlier described.
Male patients with an early diagnosis were prone to pneumonia and less prone to other complications.
Diagnosis was usually 5 years after disease onset, and usually the delayed diagnosis is in early onset patients. This is a worrying cause because a delay can lead to reduced patient survival.
Patients with low immunoglobulin does showed poor outcomes, whereas higher dosing levels were associated with reduced frequency of bacterial infections.
The authors noted that there was a wide range of how patients were being treated by doctors, showing this is truly a variable disease.