Los Angeles Allergist

Los Angeles Allergist

Alan Khadavi, MD, APC
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9001 Wilshire Blvd. Suite 204
Beverly Hills, CA 90211
Phone: 310-282-8822

16260 Ventura Blvd., Suite 140
Encino, CA 91436
Phone: 818-528-7776

November 21, 2022 by Alan Khadavi

Eczema and Hard Water, is there a link?

eczema and hard water

Does hard water affect the development of eczema? Children living in areas with hard water seem to have higher rates of eczema, raising the possibility that softening water might be an effective preventive measure. A recent study evaluated the effectiveness of home installation of water softeners in preventing the development of eczema in infants with […]

Filed Under: atopic dermatitis, Blog

September 8, 2022 by Alan Khadavi

Oclacitinib for Atopic Dermatitis (Eczema) in Dogs

oclacitinib

Oclacitinib is a potent, safe and rapidly acting anti-itching JAK inhibitor. Oclacitinib was first approved by the US FDA in 2013 to treat eczema and allergic dermatitis in dogs, it is a first generation non-selective JAK inhibitor. The treatment protocol is 0.4 to 0.6 mg/kg administered orally twice a day for 2 weeks, followed by […]

Filed Under: atopic dermatitis, biologics, Blog

June 18, 2022 by Alan Khadavi

Roflumilast and Tapinarof; Emerging Therapies for Atopic Dermatitis

roflumilast tapinarof

Roflumilast and Tapinarof are 2 emerging topical therapies that have completed or have ongoing phase 3 clinical trials, with the possibility of approval in 2022. Roflumilast is a more potent PDE4 inhibitor than crisaborloe (Eucrisa) with fewer local reactions. Tapinarof, the first therapeutic arylhydocarbon modulating agent for which the only associated local effect is noninfectious […]

Filed Under: atopic dermatitis, Blog, Medications, Uncategorized

April 19, 2022 by Alan Khadavi

Asivatrep a new topical treatment for Eczema

asivatrep cream

Asivatrep is a new potential treatment for eczema (atopic dermatitis). Atopic dermatitis is a chronic inflammatory itchy skin disease that affects up to 25% of children and 10% of adults. The cause is complex and multifactorial. Currently there are few classes of topical medications to treat it. Steroids Calcineurin inhibitors (Elidel, Protopic) Phosphodiesterase 4 inhibitors Eucrisa […]

Filed Under: atopic dermatitis, Blog, Medications

September 25, 2021 by Alan Khadavi

Opzelura (ruxolitinib) for Eczema

Opzelura

Opzelura (ruxolitinib) has been FDA approved for eczema. Opzelura is a topical JAK inhibitor, and its indicated for short term use in patients 12 and up who have mild to moderate atopic dermatitis. It is the first topical janus kinase inhibitor approved in the United States. Currently for atopic dermatitis topical treatment, the mainstay of […]

Filed Under: atopic dermatitis, Blog, Medications

September 25, 2021 by Alan Khadavi

Upadacitinib for Atopic Dermatitis (Eczema)

roflumilast tapinarof

Upadacitinib is an oral JAK1 inhibitor being developed for patients with severe atopic dermatitis. Multiple phase 2 randomized placebo controlled studies have examined the efficacy of upadacitinib in adults and adolescent patients with moderate to severe atopic dermatitis. Published in The Lancet, 2 replicate 16-week trials showed that monotherapy with upadacitinib improved symptom and disease severity compared […]

Filed Under: atopic dermatitis, Blog

August 29, 2021 by Alan Khadavi

Eczema and Dementia Risk

asivatrep cream

Past studies have suggested that there is a link between eczema and dementia. Patients with dementia have a higher prevalence of eczema than those without. According the the World Health Organization, eczema (atopic dermatitis) is 15th among all nonfatal diseases and is the largest disease burden among all skin diseases.  Eczema peaks in early childhood, […]

Filed Under: atopic dermatitis, Blog

May 11, 2021 by Alan Khadavi

Abrocitinib vs. Dupilumab for Atopic Dermatitis

abrocitinib vs. dupilumab

Abrocitinib vs. Dupilumab will be an important question for many prescribing doctors with the expected FDA approval of abrocitinib soon. We have extensively discussed atopic dermatitis (eczema) in the past. For many years only topical therapies were available for this condition. Topical steroids are the mainstays of treatment, and after many years newer topical therapies […]

Filed Under: atopic dermatitis, biologics, Blog

April 27, 2021 by Alan Khadavi

Baricitinib for Atopic Dermatitis (Eczema)

asivatrep cream

Baricitinib is currently being studied for the treatment of atopic dermatitis. Baricitinib is part of the family of oral Janus kinase inhibitors that are an emerging modality in the treatment of chronic allergic inflammatory disorders due to their ability to inhibit signaling of multiple pathways of cytokines. We discussed in another blog post, Abrocitinib which is […]

Filed Under: atopic dermatitis, Blog, Medications

May 12, 2020 by Alan Khadavi

Omalizumab for Atopic Dermatitis

antihistamines before allergy shots

Omalizumab for atopic dermatitis has shown promising results. In JAMA Pediatrics, the researchers have demonstrated for the first time that omalizumab, which neutralizes IgE, reduced disease severity and improved quality of life in pediatric patients  with severe atopic dermatitis.  This was the case even in subjects with very high baseline total plasma IgE levels. Omaizumab […]

Filed Under: atopic dermatitis, biologics, Blog

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