Approximately 1 in 4 adults report the onset of adult eczema and the rest its onset is from childhood. Eczema is an ill-defined skin lesions and it includes patches, papules, and plaques with different degrees of redness and swelling. It can affect any skin site but they most classically affect the creases of the elbows […]
Fezakinumab an IL-22 antagonist for Eczema
IL-22 upregulation characterizes atopic dermatitis lesions. However, blocking IL-22 has not been defined in human subjects. A recent study sought to evaluate the cellular and molecular effects of fezakinumab (anti-IL-22) versus placebo taken from biopsy specimens. Atopic dermatitis is the most common chronic inflammatory skin disease with increasing prevalence. IL-4 and IL-13 are the 2 […]
Tralokinumab for Atopic Dermatitis
Tralokinumab is a fully human monclonal antibody that potently and specifically neutralizes IL-13. IL-13 has an important role in atopic dermatitis pathogenesis. Atopic dermatitis (eczema) is a chronic inflammatory skin disease. It can affect sleep, psychosocial activities and health related quality of life. The symptoms of many patients are not controlled with current treatment regimens. […]
New Eczema Medications in the Pipeline
In the past year or so, new eczema medications have been released that have been highly beneficial for patients. We have seen Eucrisa (crisaborole) New Eczema Medication gets FDA Approval, this is a topical medication which is an inhibitor of phosphodiesterase 4-depndent cyclic adenosine monophosphate degradation. It was approved in 2016 for mild to moderate atopic […]
Food Allergy and C-sections, what is the influence?
A recent study looked at the correlation of food allergy and birth conditions. Namely the association between C-sections, preterm birth, low birth weight, small for gestational age, large for gestational age and low Apgar scores and future food allergy. The prevalence of food allergy is increasing and there is an interest in environmental components, very […]
Common Eczema Triggers
Eczema is a dry, red, itchy skin condition. It affects approximately 10% of the population in the United States, it is most commonly found in children, but it can affect adults as well. Eczema or atopic dermatitis is often triggered by food or environmental allergens. Contact dermatitis is a reaction to allergens and irritants such […]
PR022 for Atopic Dermatitis (Eczema)
PR022 is a new topical gel being studied for the treatment of atopic dermatitis. It is entering Phase 2 trials and it is being manufactured by Realm Therapeutics. Data is supposed to come out in the 3rd quarter of 2018. PR022 consists of hypochlorous acid (HOCL). HOCL is an ideal wound care agent with powerful […]
Food Diversity and Allergic Disease
Food diversity has been a hot topic in allergy since several clinical trials in high-risk children reported that early introduction of highly allergenic foods, especially peanut and egg, prevents food allergy later in life. This opened up the debate about changing recommendations about the timing of solid food introduction and the length of breast feeding […]
Do Bleach Baths Improve Eczema?
Eczema or atopic dermatitis is a chronic, relapsing inflammatory skin disorder affecting 15%-20% of children and 1%-10% of adults in the U.S. and worldwide. Deficiencies in the skin barrier and immune system dysfunction contribute to eczema, resulting in dryness and itching. Eczema patients are predisposed to to skin infections and patients have a high concentration […]
Criteria for Dupixent (dupilumab) for Eczema
There is no set criteria for dupixent (dupilumab), but there are guidelines in place that Regeneron and Sanofi recommend to get patients enrolled through their insurance companies. Every insurance company has their own criteria, but under Regeneron and Sanofi’s, Dupixent My Way, they set out guidelines which would help get approval easier for Dupixent. Being a very […]