Los Angeles Allergist

Los Angeles Allergist

Alan Khadavi, MD, APC
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9001 Wilshire Blvd. Suite 204
Beverly Hills, CA 90211
Phone: 310-282-8822

16260 Ventura Blvd., Suite 140
Encino, CA 91436
Phone: 818-528-7776

April 19, 2022 by Alan Khadavi

Asivatrep a new topical treatment for Eczema

asivatrep cream

Asivatrep is a new potential treatment for eczema (atopic dermatitis). Atopic dermatitis is a chronic inflammatory itchy skin disease that affects up to 25% of children and 10% of adults. The cause is complex and multifactorial. Currently there are few classes of topical medications to treat it. Steroids Calcineurin inhibitors (Elidel, Protopic) Phosphodiesterase 4 inhibitors Eucrisa […]

Filed Under: atopic dermatitis, Blog, Medications

September 25, 2021 by Alan Khadavi

Opzelura (ruxolitinib) for Eczema

Opzelura

Opzelura (ruxolitinib) has been FDA approved for eczema. Opzelura is a topical JAK inhibitor, and its indicated for short term use in patients 12 and up who have mild to moderate atopic dermatitis. It is the first topical janus kinase inhibitor approved in the United States. Currently for atopic dermatitis topical treatment, the mainstay of […]

Filed Under: atopic dermatitis, Blog, Medications

September 25, 2021 by Alan Khadavi

Upadacitinib for Atopic Dermatitis (Eczema)

upadacitinib

Upadacitinib is an oral JAK1 inhibitor being developed for patients with severe atopic dermatitis. Multiple phase 2 randomized placebo controlled studies have examined the efficacy of upadacitinib in adults and adolescent patients with moderate to severe atopic dermatitis. Published in The Lancet, 2 replicate 16-week trials showed that monotherapy with upadacitinib improved symptom and disease severity compared […]

Filed Under: atopic dermatitis, Blog

August 29, 2021 by Alan Khadavi

Eczema and Dementia Risk

asivatrep cream

Past studies have suggested that there is a link between eczema and dementia. Patients with dementia have a higher prevalence of eczema than those without. According the the World Health Organization, eczema (atopic dermatitis) is 15th among all nonfatal diseases and is the largest disease burden among all skin diseases.  Eczema peaks in early childhood, […]

Filed Under: atopic dermatitis, Blog

May 11, 2021 by Alan Khadavi

Abrocitinib vs. Dupilumab for Atopic Dermatitis

abrocitinib vs. dupilumab

Abrocitinib vs. Dupilumab will be an important question for many prescribing doctors with the expected FDA approval of abrocitinib soon. We have extensively discussed atopic dermatitis (eczema) in the past. For many years only topical therapies were available for this condition. Topical steroids are the mainstays of treatment, and after many years newer topical therapies […]

Filed Under: atopic dermatitis, biologics, Blog

April 27, 2021 by Alan Khadavi

Baricitinib for Atopic Dermatitis (Eczema)

asivatrep cream

Baricitinib is currently being studied for the treatment of atopic dermatitis. Baricitinib is part of the family of oral Janus kinase inhibitors that are an emerging modality in the treatment of chronic allergic inflammatory disorders due to their ability to inhibit signaling of multiple pathways of cytokines. We discussed in another blog post, Abrocitinib which is […]

Filed Under: atopic dermatitis, Blog, Medications

May 12, 2020 by Alan Khadavi

Omalizumab for Atopic Dermatitis

antihistamines before allergy shots

Omalizumab for atopic dermatitis has shown promising results. In JAMA Pediatrics, the researchers have demonstrated for the first time that omalizumab, which neutralizes IgE, reduced disease severity and improved quality of life in pediatric patients  with severe atopic dermatitis.  This was the case even in subjects with very high baseline total plasma IgE levels. Omaizumab […]

Filed Under: atopic dermatitis, biologics, Blog

March 10, 2020 by Alan Khadavi

Ruxolitinib for Eczema (atopic dermatitis)

chronic spontaneous urticaria

Ruxolitinib is a new medication being studied for the treat of eczema.  Ruxolitinib is a selective inhibitor of Janus kinase 1 and Janus kinase 2, it potently suppresses cytokine signaling involved in atopic dermatitis pathogenesis. We discussed the Janus Kinase pathway in a previous post and how new drugs are being developed for the treatment […]

Filed Under: atopic dermatitis, biologics, Blog

January 21, 2020 by Alan Khadavi

New treatments for eczema on the horizon

abrocitinib vs. dupilumab

Eczema is an inflammatory skin disease that results in a rash and itching. This impacts a patients quality of life including depression, sleep disturbances and even suicidal ideation.  Treatments include, moisturizers, topical steroids and calineurin inhibitiors. Despite treatment, many patients still suffer.  Advances in recent years have brought new medications, Dupilumab and Eucrisa. Although they […]

Filed Under: atopic dermatitis, Blog

January 9, 2020 by Alan Khadavi

Delgocitinib for patients with atopic dermatitis

abrocitinib vs. dupilumab

Topical delgocitinib (JTE-052) is a novel Janus kinase inhibitor that has been shown to be effective in adults with eczema. Eczema is an itchy, inflammatory skin rash that lasts chronically and it can fluctuate.  It is seen more in childhood and the majority of patients experience resolution with age. The goal of treatment is to […]

Filed Under: atopic dermatitis, Blog, Pediatric

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