Los Angeles Allergist

Los Angeles Allergist

Alan Khadavi, MD, APC
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9001 Wilshire Blvd. Suite 204
Beverly Hills, CA 90211
Phone: 310-282-8822

16260 Ventura Blvd., Suite 140
Encino, CA 91436
Phone: 818-528-7776

March 13, 2023 by Alan Khadavi

Tezspire vs. Nucala vs. Fasenra vs. Dupixent for Eosinophilic Asthma, a comparison

Tezspire vs. Nucala vs. Fasenra vs. Dupixent

With the influx of new biological medications for asthma, the question is which one is the best to use in comparing Tezspire, Nucala, Fasenra and Dupixent? In many individuals, asthma remains uncontrolled despite the use of inhaled steroids, the use of new biological injections can improve symptoms greatly. There are no head to head trials […]

Filed Under: Asthma, biologics, Blog

December 23, 2022 by Alan Khadavi

Remibrutinib, a BTK inhibitor for Chronic Hives

remibrutininb

Remibrutinib is a highly selective oral, novel covalent Bruton tyrosine kinase inhibitor that might be effective in chronic spontaneous urticaria. Chronic spontaneous urticaria is characterized by the occurrence of itchy wheals and/or swelling lasting 6 weeks or more. Chronic hives affects about 1% of the population. First line treatment is the use of a non-sedating […]

Filed Under: biologics, Blog

November 19, 2022 by Alan Khadavi

Nucala, Fasenra or Dupixent for Severe Eosinophilic Asthma?

nucala fasenra dupixent

With the advent of new biological medications for severe eosinophilic asthma, patients have improved significantly.  Approximately 10% of individuals with asthma have severe disease, and this accounts for most asthma related morbidity and mortality. Previously the mainstay of treatment was inhaled steroids and beta agonists. In patients with severe asthma who have high eosinophils (greater […]

Filed Under: Asthma, biologics, Blog

November 18, 2022 by Alan Khadavi

Xolair for idiopathic angioedema

xolair for idiopathic angioedema

Xolair for idiopathic angioedema may be used as treatment for patients who are suffering from uncontrolled swelling. Currently Xolair is approved for chronic idiopathic urticaria. But the underlying disease mechanism of chronic hives is similar to idiopathic angioedema. Omalizumab (Xolair) for treating Angioedema and Chronic Hives Xolair for Idiopathic Anaphylaxis Angioedema is defined as recurrent […]

Filed Under: biologics, Blog

September 8, 2022 by Alan Khadavi

Oclacitinib for Atopic Dermatitis (Eczema) in Dogs

oclacitinib

Oclacitinib is a potent, safe and rapidly acting anti-itching JAK inhibitor. Oclacitinib was first approved by the US FDA in 2013 to treat eczema and allergic dermatitis in dogs, it is a first generation non-selective JAK inhibitor. The treatment protocol is 0.4 to 0.6 mg/kg administered orally twice a day for 2 weeks, followed by […]

Filed Under: atopic dermatitis, biologics, Blog

July 5, 2022 by Alan Khadavi

Itepekimab (Anti IL-33) & Brodalumab (Anti IL-25) for Asthma

Itepekimab and Brodalumab

Itepekimab and Brodalumab are two biologic medications being studied for asthma. Current biologics including Xolair, Nucala, Fasenra and Dupixent target downstream IgE, cytokines IL-5 and IL-4/13, have shown promising effects in terms of reduced asthma exacerbation rates, oral steroids, improved breathing capacity and asthma scores. However approximately 30% of patients receiving biologics do not improve […]

Filed Under: Asthma, biologics, Blog

May 24, 2022 by Alan Khadavi

Lirentelimab study for Chronic Urticaria (Hives)

remibrutininb

Lirentelimab is an anti-sialic acid-binding immunoglobulin-like lectin 8 mAb that selectively inhibits mast cells and depletes eosinophils. It is being studied for chronic urticaria that is often refractory to standard therapy. Stepwise approach to Chronic Urticaria (Chronic Hives) Chronic urticaria is a mast cell disease that causes recurrent itching, hives and angioedema for more than […]

Filed Under: biologics, Blog

May 24, 2022 by Alan Khadavi

Dupixent for EoE (Eosinophilic Esophagitis); FDA approved and New Dosing

dupixent for eoe

Dupixent for EoE (eosinophilic esophagitis) was recently approved by the FDA. This will be the first drug officially approved for EoE. Eosinophilic Esophagitis is a chronic inflammatory immune disorder of the esophagus where eosinophils (a type of white blood cell) builds up in the esophagus. This can cause symptoms of difficulty swallowing, eating or food […]

Filed Under: biologics, Blog

April 26, 2022 by Alan Khadavi

Best Nasal Polyps Treatment

best nasal polyps treatment

With so many options available, the best nasal polyps treatment can be hard to pick. Chronic rhinosinusitis with nasal polyps is an inflammatory disease of the upper airways characterized by polyp growth in the nasal passages. It causes severe congestion, discharge and difficulty with smell. The best treatment option is unclear. A study published in […]

Filed Under: biologics, Blog

April 19, 2022 by Alan Khadavi

Fasenra for Nasal Polyps, a new treatment option

fasenra for nasal polyps

Fasenra for nasal polyps is currently being studied as a future therapeutic option. Chronic sinusitis with nasal polyps is an inflammatory condition associated with symptoms that may be severe, including rhinorrhea, nasal blockage and congestion, loss of smell, facial pressure/pain. Nasal sprays have shown limited help and surgery only helps temporarily as many of them […]

Filed Under: biologics, Blog

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March 13, 2023

Tezspire vs. Nucala vs. Fasenra vs. Dupixent for Eosinophilic Asthma, a comparison

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Cucumber Allergy can come in many flavors

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Airsupra for Asthma, a new rescue medication

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December 23, 2022

Remibrutinib, a BTK inhibitor for Chronic Hives

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November 21, 2022

Eczema and Hard Water, is there a link?

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November 19, 2022

Nucala, Fasenra or Dupixent for Severe Eosinophilic Asthma?

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