Los Angeles Allergist

Los Angeles Allergist

Alan Khadavi, MD, APC
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9001 Wilshire Blvd. Suite 204
Beverly Hills, CA 90211
Phone: 310-282-8822

16260 Ventura Blvd., Suite 140
Encino, CA 91436
Phone: 818-528-7776

July 5, 2022 by Alan Khadavi

Itepekimab (Anti IL-33) & Brodalumab (Anti IL-25) for Asthma

Itepekimab and Brodalumab

Itepekimab and Brodalumab are two biologic medications being studied for asthma. Current biologics including Xolair, Nucala, Fasenra and Dupixent target downstream IgE, cytokines IL-5 and IL-4/13, have shown promising effects in terms of reduced asthma exacerbation rates, oral steroids, improved breathing capacity and asthma scores. However approximately 30% of patients receiving biologics do not improve […]

Filed Under: Asthma, biologics, Blog

May 24, 2022 by Alan Khadavi

Lirentelimab study for Chronic Urticaria (Hives)

lirentelimab

Lirentelimab is an anti-sialic acid-binding immunoglobulin-like lectin 8 mAb that selectively inhibits mast cells and depletes eosinophils. It is being studied for chronic urticaria that is often refractory to standard therapy. Stepwise approach to Chronic Urticaria (Chronic Hives) Chronic urticaria is a mast cell disease that causes recurrent itching, hives and angioedema for more than […]

Filed Under: biologics, Blog

May 24, 2022 by Alan Khadavi

Dupixent for EoE (Eosinophilic Esophagitis); FDA approved and New Dosing

dupixent for eoe

Dupixent for EoE (eosinophilic esophagitis) was recently approved by the FDA. This will be the first drug officially approved for EoE. Eosinophilic Esophagitis is a chronic inflammatory immune disorder of the esophagus where eosinophils (a type of white blood cell) builds up in the esophagus. This can cause symptoms of difficulty swallowing, eating or food […]

Filed Under: biologics, Blog

April 26, 2022 by Alan Khadavi

Best Nasal Polyps Treatment

best nasal polyps treatment

With so many options available, the best nasal polyps treatment can be hard to pick. Chronic rhinosinusitis with nasal polyps is an inflammatory disease of the upper airways characterized by polyp growth in the nasal passages. It causes severe congestion, discharge and difficulty with smell. The best treatment option is unclear. A study published in […]

Filed Under: biologics, Blog

April 19, 2022 by Alan Khadavi

Fasenra for Nasal Polyps, a new treatment option

fasenra for nasal polyps

Fasenra for nasal polyps is currently being studied as a future therapeutic option. Chronic sinusitis with nasal polyps is an inflammatory condition associated with symptoms that may be severe, including rhinorrhea, nasal blockage and congestion, loss of smell, facial pressure/pain. Nasal sprays have shown limited help and surgery only helps temporarily as many of them […]

Filed Under: biologics, Blog

March 8, 2022 by Alan Khadavi

Itepekimab in Asthma and COPD

itepekimab for asthma

Itepekimab is an anti-Il-33 monoclonal. Il-33 is an epithelium-derived cytokine that promotes Th2 immune responses in response to cellular damage with roles in asthma and COPD (Chronic Obstructive Pulmonary Disease). Two randomized controlled clinical trials were performed assessing the efficacy of Itepekimab in asthma and COPD. After identifying the asthma associated variants in the genes […]

Filed Under: Asthma, biologics, Blog

February 12, 2022 by Alan Khadavi

Xolair, Dupixent or Nucala for Nasal Polyps?

dupixent xolair nucala nasal polyps

Xolair, Dupixent and Nucala all have the indication to treat chronic rhinosinusitis with nasal polyps. Conventional treatment involves nasal surgery (debulking polypectomy and sinus surgery to create open sinus cavities and improve ostiomeatal complex drainage). Many patients relapse despite medical and surgical treatment. 3 current medications are used to target type 2 inflammation to improve […]

Filed Under: biologics, Blog

January 6, 2022 by Alan Khadavi

New Eosinophilic Esophagitis Treatments

dupixent for eoe

New Eosinophilic esophagitis treatments are currently being studied. As of today, there are no eosinophilic esophagitis treatments that are FDA approved. On the horizon is Eohilia Budesonide Oral Suspension for Eosinophilic Esophagitis. Plus there are many other ways that EoE can be treated, but there are no official medications yet. Here we will discuss new eosinophilic […]

Filed Under: Allergy Medicine, biologics, Blog

July 9, 2021 by Alan Khadavi

Nasal Polyps Treatment; Past, Present and Future

best nasal polyps treatment

Nasal polyps treatment have shown great advances recently, and many more treatments are on the horizon. Nasal polyps are used to describe chronic rhinosinusitis associated with the formation of nasal polyps.  Nasal polyps affect 2-4% of adults globally. About 50% of patients have existing allergies. Nasal polyps are semitranslucent, pale grey, grape-like, benign inflammatory lesions […]

Filed Under: Allergy Medicine, biologics, Blog, Medications, Uncategorized

May 11, 2021 by Alan Khadavi

Abrocitinib vs. Dupilumab for Atopic Dermatitis

abrocitinib vs. dupilumab

Abrocitinib vs. Dupilumab will be an important question for many prescribing doctors with the expected FDA approval of abrocitinib soon. We have extensively discussed atopic dermatitis (eczema) in the past. For many years only topical therapies were available for this condition. Topical steroids are the mainstays of treatment, and after many years newer topical therapies […]

Filed Under: atopic dermatitis, biologics, Blog

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July 5, 2022

Itepekimab (Anti IL-33) & Brodalumab (Anti IL-25) for Asthma

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June 18, 2022

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June 9, 2022

Avocado Allergy Comes in Many Flavors

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May 24, 2022

Lirentelimab study for Chronic Urticaria (Hives)

lirentelimab

May 24, 2022

Dupixent for EoE (Eosinophilic Esophagitis); FDA approved and New Dosing

dupixent for eoe

April 30, 2022

What are the best foods for Asthma?

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April 26, 2022

Best Nasal Polyps Treatment

best nasal polyps treatment

April 19, 2022

Fasenra for Nasal Polyps, a new treatment option

fasenra for nasal polyps

April 19, 2022

Asivatrep a new topical treatment for Eczema

asivatrep cream

April 3, 2022

Kiwi Allergy can come in many flavors

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