There can be many ways to treat eosinophilic esophagitis (EoE). This is a chronic allergic inflammatory disease that affects the esophagus. Diagnosis involves having esophageal symptoms and finding 15 or more eosinophils per high power field on biopsy in the absence of other causes. The most classical symptom seen in adults is difficulty swallowing, other […]
Can the Covid Vaccine cause Hives?
Physicians have seen an increase of hives in patients following the Covid vaccine, but to date there have been no formal studies documenting patients who already have existing chronic urticaria. The rapid development and rollout of the vaccine for COVID-19 has led to unexpected adverse reactions during mass vaccination. Delayed onset hives is a common […]
Dupixent for COPD, a new indication
Dupixent for COPD is currently being studied and seeking an approval for this new indication. Type 2 inflammation is present in a significant portion of patients with COPD and it increases the exacerbation risk. A recent study published in the New England Journal of Medicine performed a randomized, placebo controlled phase 3 trial to investigate […]
A comparison of asthma biologic therapies
A comparison of asthma biologic therapies have not been directly done. A recent study published in the [Annals of of Allergy, Asthma and Immunology 130 (2023) pg 595-606], sought to do that. They compared Dupixent, Tezspire, Xolair, Cinqair, Nucala, Fevipiprant, and Fasenra. 64 trials were included, consisting of more than 25,000 patients. The optimal biologic […]
Xolair vs. Nucala vs. Dupixent in Asthma, which is the best?
Xolair vs. Nucala vs. Dupixent Multiple biologics are approved for the the treatment of severe asthma. However, there are no head to head studies comparing them. Many patients can potentially be approved for multiple of them and it can be difficult to choose which would work best. So the optimal choice may be uncertain. All […]
Tezspire vs. Nucala vs. Fasenra vs. Dupixent for Eosinophilic Asthma, a comparison
With the influx of new biological medications for asthma, the question is which one is the best to use in comparing Tezspire, Nucala, Fasenra and Dupixent? In many individuals, asthma remains uncontrolled despite the use of inhaled steroids, the use of new biological injections can improve symptoms greatly. There are no head to head trials […]
Remibrutinib, a BTK inhibitor for Chronic Hives
Remibrutinib is a highly selective oral, novel covalent Bruton tyrosine kinase inhibitor that might be effective in chronic spontaneous urticaria. Chronic spontaneous urticaria is characterized by the occurrence of itchy wheals and/or swelling lasting 6 weeks or more. Chronic hives affects about 1% of the population. First line treatment is the use of a non-sedating […]
Nucala, Fasenra or Dupixent for Severe Eosinophilic Asthma?
With the advent of new biological medications for severe eosinophilic asthma, patients have improved significantly. Approximately 10% of individuals with asthma have severe disease, and this accounts for most asthma related morbidity and mortality. Previously the mainstay of treatment was inhaled steroids and beta agonists. In patients with severe asthma who have high eosinophils (greater […]
Xolair for idiopathic angioedema
Xolair for idiopathic angioedema may be used as treatment for patients who are suffering from uncontrolled swelling. Currently Xolair is approved for chronic idiopathic urticaria. But the underlying disease mechanism of chronic hives is similar to idiopathic angioedema. Omalizumab (Xolair) for treating Angioedema and Chronic Hives Xolair for Idiopathic Anaphylaxis Angioedema is defined as recurrent […]
Oclacitinib for Atopic Dermatitis (Eczema) in Dogs
Oclacitinib is a potent, safe and rapidly acting anti-itching JAK inhibitor. Oclacitinib was first approved by the US FDA in 2013 to treat eczema and allergic dermatitis in dogs, it is a first generation non-selective JAK inhibitor. The treatment protocol is 0.4 to 0.6 mg/kg administered orally twice a day for 2 weeks, followed by […]