Fasenra for nasal polyps is currently being studied as a future therapeutic option. Chronic sinusitis with nasal polyps is an inflammatory condition associated with symptoms that may be severe, including rhinorrhea, nasal blockage and congestion, loss of smell, facial pressure/pain. Nasal sprays have shown limited help and surgery only helps temporarily as many of them […]
Itepekimab in Asthma and COPD
Itepekimab is an anti-Il-33 monoclonal. Il-33 is an epithelium-derived cytokine that promotes Th2 immune responses in response to cellular damage with roles in asthma and COPD (Chronic Obstructive Pulmonary Disease). Two randomized controlled clinical trials were performed assessing the efficacy of Itepekimab in asthma and COPD. After identifying the asthma associated variants in the genes […]
Xolair, Dupixent or Nucala for Nasal Polyps?
Xolair, Dupixent and Nucala all have the indication to treat chronic rhinosinusitis with nasal polyps. Conventional treatment involves nasal surgery (debulking polypectomy and sinus surgery to create open sinus cavities and improve ostiomeatal complex drainage). Many patients relapse despite medical and surgical treatment. 3 current medications are used to target type 2 inflammation to improve […]
New Eosinophilic Esophagitis Treatments
New Eosinophilic esophagitis treatments are currently being studied. As of today, there are no eosinophilic esophagitis treatments that are FDA approved. On the horizon is Eohilia Budesonide Oral Suspension for Eosinophilic Esophagitis. Plus there are many other ways that EoE can be treated, but there are no official medications yet. Here we will discuss new eosinophilic […]
Nasal Polyps Treatment; Past, Present and Future
Nasal polyps treatment have shown great advances recently, and many more treatments are on the horizon. Nasal polyps are used to describe chronic rhinosinusitis associated with the formation of nasal polyps. Nasal polyps affect 2-4% of adults globally. About 50% of patients have existing allergies. Nasal polyps are semitranslucent, pale grey, grape-like, benign inflammatory lesions […]
Abrocitinib vs. Dupilumab for Atopic Dermatitis
Abrocitinib vs. Dupilumab will be an important question for many prescribing doctors with the expected FDA approval of abrocitinib soon. We have extensively discussed atopic dermatitis (eczema) in the past. For many years only topical therapies were available for this condition. Topical steroids are the mainstays of treatment, and after many years newer topical therapies […]
Xolair for Allergic Rhinitis-A recent study
Xolair for allergic rhinitis may become a future treatment option for patients. Currently Xolair which is an anti-IgE antibody is indicated for moderate to severe persistent asthma and chronic idiopathic urticaria. But the mechanism of action lends itself to treating allergic rhinitis. Allergic rhinitis is one of the most common and increasing diseases worldwide, affecting […]
Xolair for Nasal Polyps
The treatment of Xolair for nasal polpys is currently being investigated. Chronic sinusitis with nasal polyps is common and is estimated to affect up to 15% of the population. It is associated with adult onset asthma. Many patients have uncontrolled symptoms despite use of nasal steroids. Even after surgery up to 80% of patients can […]
Covid with Xolair, Nucala, Cinqair, Fasenra or Dupixent for Asthma
As Covid-19 continues to spread around the world, there are concerns that patients with asthma will be at higher risk or poorer outcomes. There is also concern about whether asthma treatments could worsen the risk of disease or severity. Currently, asthma is not in the top 10 comorbidities associated with Covid-19 fatalities, obesity, diabetes and […]
New Treatment for Hives being studied
The current only approved treatment for hives are antihistamines and Xolair (omalizumab). Omalizumab is approved for the treatment of chronic hives for those 12 years and older (it is approved for 6 years and older in asthma). New treatment for hives are on the horizon. Stepwise approach to Chronic Urticaria (Chronic Hives) Ligelizumab is a […]